Tag Archives: Delhi University

Indian scientists develop new approach to combat TB

Dr Swati Subodh

Prof. Anil K. Tyagi (right) with fellow researchers

New Delhi: A group of Indian scientists have identified molecules which are effective in inhibiting the growth of tuberculosis-causing bacteria – Mycobacterium tuberculosis.

The molecules target an important gene, IdeR, which is essential for the survival of the bacteria. This development could lead to new drugs against TB in future. “We have identified inhibitory molecules against IdeR, a key iron regulator that is crucial for survival of the TB pathogen,” said Prof. Anil K. Tyagi, a senior scientist at the University of Delhi and lead researcher of the study. The findings have been published in the journal Scientific Reports.

//pagead2.googlesyndication.com/pagead/js/adsbygoogle.js

(adsbygoogle = window.adsbygoogle || []).push({});

In laboratory studies, the new molecules were not toxic in human liver cells and kidney cells and could efficiently reach the bacteria present within the cell, researchers said.
For decades treatment of TB has remained unchanged. Patients have to take multiple drugs over 6 to 9 months, which makes the treatment effective but largely inefficient due to associated side effects and high rate of patient non-compliance. This, in turn, increases the risk of developing drug resistant form of TB which is difficult to treat. Therefore, scientists are searching for better treatment which is shorter in duration and requires fewer drugs.

“We employed computer aided drug discovery and experimental approaches to identify inhibitors against an essential protein of TB bacteria,” explained Dr Garima Khare, one of the lead researchers. In doing so, researchers were able to identify additional features that contribute to better inhibition of this protein’s activity.

The study holds promise as it reports the structure and properties of likely drug molecules which are effective in inhibiting the bacteria by targeting a single essential bacterial gene vis-a-vis the multi-gene approach of the present treatment regimen.

//pagead2.googlesyndication.com/pagead/js/adsbygoogle.js

(adsbygoogle = window.adsbygoogle || []).push({});

“These inhibitors will open new avenues for rational modifications for developing more potent molecules against IdeR for the development of new TB drugs” hopes Prof Tyagi.

The study was conducted at Department of Biochemistry, University of Delhi South campus by Akshay Rohilla, Dr Garima Khare and Dr Anil.K Tyagi. The research was funded by the Department of Biotechnology (DBT). (India Science Wire)


Twitter handle: @swatisubodh

 

Scientists decipher why epilepsy drugs don’t work for some women

Bhavya Khullar

New Delhi: Effective treatment is available for epilepsy. Yet doctors find that epilepsy drugs don’t work in some women. Now scientists have figured out why some women suffer from recurrent seizures despite medication.

Scientists at Institute of Genomics and Integrative Biology (IGIB) and Institute of Human Behavior and Allied Sciences (IHBAS), both in New Delhi, have found that a variation in a gene called Cytochrome P4501A1 (CYP1A1) is responsible for some women to suffer from frequent epileptic seizures despite taking one or a combination of known anti-epileptic drugs. The study results have been published in The Pharmacogenomics Journal.

CYP1A1 gene is known to make an enzyme that regulates the levels of female hormone estrogen in the blood which is also important in controlling drug response in epilepsy. “Since this gene is involved in dispersal of estrogen, we thought that perhaps an altered expression of itis contributing to higher levels of estradiol, which, in turn, was increasing susceptibility of women to seizure and causing poor response to drugs. Our studies showed this was indeed so,” researchers explained. The study involved 579 patients with epilepsy, of whom 45% were women.

Based on the study results, the researchers have identified a genetic marker for predicting therapeutic response to drugs in epilepsy.

“Though genetic variation has been studied in other countries with variable results, this study in the Indian context is important. We still are trying to find out best management for intractable seizure. Hopefully the new finding about genetic basis of intractable seizures will lead to some better enzyme regulation in anti-epileptic drugs in future”, commented Dr Vijaya Nath Mishra, professor of neurology at the Institute of Medical Sciences (IMS) BHU, who was not involved in this study.

The research team included P Talwar, N Kanojia, S Mahendru, R Baghel, S Grover, G Arora, GK Grewal, S Parween, A Srivastava, M Singh, S Vig, S Kushwaha, S Sharma, K Bala, S Kukreti, and Ritushree Kukreti. (India Science Wire)


Twitter handle: BhavyaSc

University World Rankings: Punjab University does it again

Rajiv Lochan

Punjab University does it again. Outranks the other great universities of India. For such consistently great performance we need to notice that Punjab University is the quintessential old fashioned university, made up of a variety of characters, ideas and behaviour patterns, each jostling with each other for space within the campus and hopefully enriching student lives far beyond they would have experienced on any other Indian university except perhaps the IITs.

Gandhi Bhawan, an architectural landmark, from the days when PU had enough money to fill the pond with water.
Gandhi Bhawan, an architectural landmark, from the days when PU had enough money to fill the pond with water.

In India two universities have featured in the university world rankings and been placed in the top slot of 500-601: one is Panjab University and the other is Jadavpur University.

After that, in the 601-800 slot come Aligarh Muslim University, Delhi University and Pune University. The other universities of India are so far behind that they don’t even get counted.

The performance of Panjab University is doubly commendable since it has been able to maintain this position despite most of the high end research being done at PU being not counted ‘because it involved far too intense a collaboration across nations’. So the efforts of the faculty members from the High Energy Lab at PU were not counted at all.

Furthermore, Panjab University has been consistently tied up for funds– with the UGC refusing to release funds on time, siphoning off funds that are allotted to PU to other heads.

Punjab University’s performance is even more commendable considering that

  • PU has maintained a top position for over six years now
  • PU has refused to increase student fee for over twenty years despite the UGC continuously pressing for doubling or trebling of the fee– a diktat that was quickly followed by all other universities (except perhaps some central universities)
  • PU pays even its adjunct faculty proper salaries rather than exploit them like almost all other universities and colleges do on a point to point basis,
  • PU produces at least three times better results per rupee spent than any other university in India.

However, instead of promoting the PU model of work and performance, the government of India has consistently tried to throttle the university in various ways for over three decades.

How does PU do so? Because of its mixed up character. It is a mixed up campus. And that makes for its creativity and productivity.

The university should always be so mixed up: there is a bunch that spends time at Students’ Common, another bunch just does geris, yet another picks up guns and fires a few shots at perceived enemies, some join the government as officers, others as ministers, some as office assistants. Some are happy teaching in a school. Some go into banks and businesses and make millions. A few try to overthrow the government through rebellions, armed or otherwise. There are yet others who try to catch the rebellious ones and put them in jail. While some others provide legal support to one side, there are others who provide legal support to the opposite. Yet others sit in judgement over everyone. A handful even get into the library and labs and produce results that (as yet) are not great prize winning but sufficient to win accolades.


Rajiv Lochan
Rajiv Lochan

The Author, a Jawaharlal Nehru University alumnus, is a renowned historian.

Police busts a Delhi University admission racket, four arrested

Newsroom24x7 Staff

 

Delhi UniversityNew Delhi: Delhi Crime Branch has busted a racket à la VYAPAM involved in arranging admissions in prestigious colleges of South and North campuses of Delhi University on the basis of forged certificates and documents.

Four persons including a student – Sunil Panwar alias Guruji (41) s/o Ram Chander Panwar r/o 295/4Mehrauli, Mohd. Juber (25) s/o Sher Mohd. r/o 149, HauzRani, Ranchit Khurana (30) s/o Ashok Khurana r/o 735,Sec- 29, Noida and Praveen Jha (35) s/o Kala Dhar Jha r/o C-469, West Vinod Nagarhave been arrested. Large number of forged mark-sheets, degrees, character certificates, computer, 3 printers and 40 stamps of different government universities, education boards and colleges along with forged signature seals of the authorized signatories have been recovered from them.

According to Delhi POlice, information was received by Assistant Sub-Inspector (ASI) Dharmender that three persons involved in getting students admitted in prestigious colleges of South and North campus of Delhi University on the basis of forged mark-sheets/documents would come to main market Malviya Nagar in an Ertiga car. Thereafter a team of South Eastern Range led by ACP KPS Malhotra and comprising of Inspector Pankaj Singh, sub-inspectors Vishal, Omveer Singh, ASI Dharmender, head constables Jagpal, Sunil Gaur,Naresh, Pradeep, Prithvi, constables Surender, Rohit, Vinod, Sanjeev, Sandeep, Ankitand Kusumpal under the supervision of Deputy Commissioner of Police Bhisham Singh and overall supervision of Additional Commissioner of Police Alok Kumar was constituted to nab them. The team laid a trap and three suspects – Sunil Panwar alias Guruji, Mohammed Juber and Ranchit Khurana were apprehended. Large number of forged documents and stamps of different schools and education boards were recovered from their possession. A case 9FIR No.114/15 u/s 420/465/468/473/34 IPC) was registered by the Crime Branch.

During sustained interrogation, it was revealed that Sunil Panwar is the gang leader who along with Juber (a student of Aurobindo College) used to procure details of those candidates who could not get admission in a course of their choice in Delhi University. They used to give the details of these candidates to Ranchit, whose job was to get forged documents prepared from one Praveen Jha. Immediately, a raid was conducted and the accused Praveen Jha was also apprehended. Large number of blank and complete degrees, mark sheets, caste certificates and other documents were recovered from his office.

MODUS OPERANDI

The accused used to prepare the documents pertaining to Uttar Pradesh and Bihar Boards. To evade detection of the forged documents, they had even created fake websites of of Uttar Pradesh, Madhya Pradesh and Bihar Boards and were uploading the details of the fake certificates and mark-sheets on these fake websites to ensure online verification by the Delhi University colleges. They had also prepared fake degrees of various universities for the candidates who were seeking jobs in the private sector.

During the present academic year, the racketeers have managed to secure admissions for more than 25 students on the basis of forged mark sheets, caste certificates, transfer certificates, and character certificates in different prestigious colleges in South and North campuses of Delhi University.

Documents of the students, who are suspected to have secured admission on the basis of forged documents, are being obtained from the concerned colleges for further scrutiny. The racketeers used to charge Rs. 3 to 7 lac from a prospective student for getting him admitted ina college and course of his choice. The racketeers have disclosed that they were operating since last three years.
Below is the list of colleges and the number of admissions that have come under police scanner:

Colleges                                  No. of Admissions

Hindu College                                      1

Kirorimal  College                                 1

Aurobindo College (Evening)                3

Dayal Singh College (Evening)              2

Dayal Singh College (Morning)             1

Ram Lal Anand College                         2

DAV College                                       1

Bhagat Singh College                          10

\Kamla Nehru College                           1