BHEL Bhopal diary: Vigilance Awareness Week and Fire-fighting mock drill

Newsroom24x7 Staff

Bhopal: A fire-fighting mock drill by CISF was conducted today at ISRO/MCF Main Satellite Control Centre Hall to test and demonstrate fire-fighting capabilities.

The fire-fighting mock drill was organised for 70 fire-fighters from CISF- MCF/ISRO; CISF-Fire BHEL, Bhopal; NDRF, Bhopal; DSCC- Army; Bhopal City Fire Services Division, Bhopal Police and Intelligence Bureau.

On this occasion A K Kiyawat, AGM (Safety) BHEL, Bhopal; R K Meena, Sr. Engineer and Sajid Khan, Sr. Fire Officer, Bhopal Municipal Corporation were present.

The joint exercise was held at the centre under the leadership of B K Singh, Assistant Commandant, CISF (BHEL, Bhopal).

Shailendra Kumar, Manager(MCF) and Surya Prakash Tripathi, Assistant Commandant (CISF) had a special word of praise for the mock drill. Both said that it would help in further augmenting and improving the abilities of the forces.

Vigilance Awareness Week

A lecture session was also organised at the auditorium of TIT Engineering college in the State capital to mark BHEL Bhopal unit’s Vigilance Awareness Week 2017.

On this occasion, AGM (Vigilance) Sanjay Dhavle, administered the Integrity Pledge.  G.K. Dixit, who addressed the students as chief guest, said: “Eradication of corruption is essential for progress of our country. It is expected of the youth that
they will take every step to create a corruption-free environment in their respective work areas”, he observed.

Director TIT Dr. SK Jain and Professor Sukul Lomash also addressed the gathering. AGM (HRDC) Amitabh Dubey proposed the vote of thanks. The ceremony was conducted by Dr. Mrs. KV Padmaja, Dy. Mgr. (HRDC) along with the students of the college.

Officers of vigilance department Pankaj Jha DGM, BN Choudhary Sr. Engr. and Sr. Engr. (HRDC) Ms Meenakshi were present.

Diesel-Petrol VAT rate slashed in MP: Additional surcharge on diesel abolished

Newsroom24x7 Staff

Bhopal: Madhya Pradesh Chief Minister Shivraj Singh Chouhan today (13 October 20`17) announced the decision to reduce the VAT rate on diesel and petrol.

The Chief Minister further announced that the additional surcharge of Rs. 1.50 per litre charged on diesel also has been abolished.

The new rates will come in effect from midnight today. The diesel being sold at the rate of Rs. 63.31 per liter will be sold at Rs. 59.37 per liter after midnight.

Chouhan said that this decision for reduction in diesel and petrol rates has been taken to give relief to the common people and the farmers keeping in view their requirement. He said that the reduced rates of diesel and petrol will reduce the cost of freight and the goods will become cheaper.

The Chief Minister said that VAT on diesel has been reduced by 5 percent and additional surcharge of Rs. 1.50 charged on diesel has also been abolished. Similarly, VAT on petrol has been reduced by 3 percent.

Epigenetic manipulation may inhibit cancer spread

Ratneshwar Thakur

New Delhi: Manipulating tags on DNA without changing the underlying sequence triggers a chain of molecular events that may
help prevent spread of cancer, a new study by Indian scientists has revealed.

Development of cancer is a multistep process involving changes in several genes. Although the blueprint for cell’s life is kept in DNA for all events like growth, maturation, division, and even death, it is proteins that essentially do all the required work.

The new study shows epigenetics (changing activity of a DNA segment without changing sequence) anomalies could alter DNA instruction manuals for splicing that may lead to the synthesis of a particular type of mRNA and eventually proteins, in cancer cells.

In the study published in journal Proceedings of the National Academy of Sciences, Dr. Sanjeev Shukla’s group at Indian Institute of Science Education and Research (IISER), Bhopal has successfully identified a novel way to target glucose metabolism and thereby breast cancer cells by switching ‘alternative splicing’ of PKM gene.

According to the study, most of the cancer cells derive their energy from an energy production process called aerobic glycolysis that involves transformation of glucose to lactate, when limited amounts of oxygen are available. Pyruvate kinase, an enzyme that catalyzes the last step of glycolysis seems to be an important regulator of this switch in the metabolism of glucose. Out of four isozymes of pyruvate kinase, isozymes M1 and M2 result from alternative splicing of transcripts coded by the PKM gene. Interestingly, the PKM2 alternative isoform is expressed by highly proliferating cells including cancer cells suggesting that regulation of PKM1/PKM2 ratio may hold the key to regulate cancer proliferation.

Researchers have discovered that the PKM2 specific exon inclusion is regulated by DNA methylation and a CTCF related protein BORIS (Brother of Regulator of Imprinted Sites) which preferentially binds to the PKM2-specific- methylated exon. As a result of this, splicing process gets altered in the case of cancer cells in such a way that instead of exon 9, exon 10 gets included when the pre-mRNA is spliced into mRNA.


Research team at IISER

“Our study suggests, we can potentially target DNA methylation to switch the cancer-specific splicing isoform to normal isoform and thereby inhibit the growth of cancer cells,” explained Dr. Shukla, who is a Wellcome Trust/DBT India Alliance Fellow. “DNA methylation or BORIS may serve as a potential target to inhibit the growth of cancer cells. As the epigenetic marks are reversible, they are an attractive target for cancer therapy,” he added.
 
Collaborators in this study, Dr. Rajendra K. Panday and Dr. Atul Samaiya from Bansal Hospital, Bhopal say “the new findings will help in the development of potential target for cancer therapy and will be useful in patient management in future.”


 

“As a therapeutic strategy, inhibiting the growth and accelerating the death rate of breast cancer cells may be possible by starving the cancer cells of glucose or by inhibiting or reversing aerobic glycolysis. Aerobic glycolysis confers a proliferative advantage to the cancer cells. The work of Dr. Shukla's group connects DNA methylation to alternative splicing and cell proliferation suggesting that epigenetic manipulation may provide a novel approach to dysregulate RNA processing and inhibit cancer proliferation,” says Dr. Sanjeev Galande, Scientist at IISER-Pune who is not related to this study. (India Science Wire)


Twitter handle: @ratnesh_thakur